Recent favorites include:
A talk using dancers instead of PowerPoint
A woman who lost both her legs becomes a professional snowboarder
How to defend ourselves against asteroids
If you don't watch TED talks, I highly suggest you follow them on Facebook or Twitter, and try to watch daily. All the talks are short (usually under 20 minutes) - perfect for while you're eating lunch at your desk - but amazingly inspiring.
It might be one of my new life goals to give a TED talk...or maybe just to even see one.