I do not know a lot about Asperger's, but it seemed like Picoult portrayed it very well in this book. It was frustrating to read from the mother's (Emma) point of view, learning all she has to deal with and how she had to give up her whole life. But, you could also feel the love she has for her son, and how she wouldn't want him any other way. It was also interesting reading from Jacob's perspective, and I would be interested to know how accurate his portrayal is.
The plot was typical Picoult, with twists, gasp-able moments, and big court scenes. Typically good, I might add.
There were a couple things that did rub me the wrong way though:
1. The whole story wouldn't have ever developed if there was a bit of simple communication from another character - nicoleandmaggie wrote about this kind of thing just a few days ago.
2. The "connection" between vaccinations and autism was mentioned a few times, and that made my head hurt and skin crawl.
I'm giving this book a 4/5.